CHEKMENEV
LAB
Generation-3 Xenon-129 Stopped-Flow Hyperpolarizer
Generation-3 device is the most latest technology development in our lab for Stopped-Flow Xenon-129 batch-mode hyperpolarizer. This project is still ongoing in the Lab in the last phase of device automation and optimization. Similarly to gen-2 device, our gen-3 device is fully automated, but unlike gen-2, it features significantly more advanced integration and operation. This web-page will contain relevant manuals and software for device operation. As of February 2022, we have completed pilot quality assurance study for Gen-3 hyperpolarizer.
Relevant publications:
1) Birchall, J. R.; Nikolaou, P.; Coffey, A. M.; Kidd, B. E.; Irwin, R. K.; Murphy, M.; Molway, M.; Bales, L. B.; Goodson, B. M.; Barlow, M. J.; Chekmenev, E. Y., Batch-Mode Clinical-Scale Optical Hyperpolarization of Xenon-129 Using an Aluminum Jacket with Rapid Temperature Ramping. Anal. Chem. 2020, 92 (6), 4309-4316. https://doi.org/10.1021/acs.analchem.9b05051
2) Birchall, J. R.; Nikolaou, P.; Irwin, R. K.; Barlow, M. J.; Ranta, K.; Coffey, A. M.; Goodson, B. M.; Pokochueva, E. V.; Kovtunov, K. V.; Koptyug Igor, V.; Chekmenev , E. Y., Helium-Rich Mixtures for Improved Batch-Mode Clinical-Scale Spin-Exchange Optical Pumping of Xenon-129. J. Magn. Reson. 2020, 315, 106739. https://doi.org/10.1016/j.jmr.2020.106739
3) Birchall, J. R.; Chowdhury, M. R. H.; Nikolaou, P.; Chekmenev, Y. A.; Shcherbakov, A.; Barlow, M. J.; Goodson, B. M.; Chekmenev, E. Y. Pilot Quality-Assurance Study of a Third-Generation Batch-Mode Clinical-Scale Automated Xenon-129 Hyperpolarizer. Molecules 2022, 27, 1327. https://www.mdpi.com/1420-3049/27/4/1327
Resources:
1) QPC Test Laser Report after repairs 02/2020: QPC report 2020.PDF